“Unlike a standard BitLocker implementation, device encryption is enabled automatically so that the device is always protected. It's not worth it.It is also a good time to mention Microsoft Windows.ġ) Bitlocker keys are uploaded by ‘device encryption’. It's better if you find an app that can do so much better until Adobe fixes these problems. Whether for educational or recreational purposes. TL DR I don't recommend this app for anyone who wants to use this for ebooks. If there's a way you can do this in the future, that would be good as well. Even though the app has a scroller that helps you jump through the pages, it doesn't indicate which page you're going to flip to. Especially if the app has not loaded certain parts of the book yet.Īnother problem is that there isn't a simpler way to find a certain page. This happens less frequently with internet connection, but it can still happen. So when we were looking for a certain page in our ebook, the app lagged every 10-15 seconds. When you flip through pages too much, it starts to freeze for a while before you can flip the pages again. The main problem is that it lags and stops a lot if you are using it offline. There are problems that me and all of my classmates mentioned while we were using this app. It forces screens to look like weirdly distorted printed and pages and ignores years of experience that make better readers actually a pleasure to use. It seems clear that they forgot that flexibility when creating this terrible implementation of an e-book reader. This feels like the worst of a first generation app: The majority of the screen space is blank around a tiny narrow column of text that looks ridiculous justified, because it truly creates distracting volumes of white space down the middle of the page.īetter apps designed for actual readers go closer to the margin of the screen, allow you to stop justifying the text when doing so avoids that distracting white space that literally makes it harder to read, or to keep the justification when it is appropriate for the text.Īdobe’s name is synonymous with graphic design, programs like Photoshop are now so powerful and flexible that that very flexibility is intimidating to many new users. I have been reading books on my phone for more than a decade, and I’ve use lots of different apps to do it over time. The quality is so poor it is completely unreadable. Words are cut off, you can't even finish reading complete sentences because the formatting is all wonky. When you read the book in the eBook format it looks awful. But I was looking for an electronic version that I could take on the road with me and easily access when away from home. I know because I have the paperback version. Then once it was finally downloaded I was incredibly disappointed in the quality of the e-reader itself. The trouble was that you cannot use safari to download it so I had to get an all new internet browser to download it. I finally figured out what the issue was by looking at the comments on the IOS reviews page from several others that had similar issues. It was ridiculously challenging to download and I spent nearly 40 minutes trying to figure out how to download it. I want to share my extreme dissatisfaction with the quality of the eBook format. I just purchased an eBook and it required me to download this app to read it. Fun stats on how much time you are spending each day to read your book, and moreīy downloading, you agree to the Terms of Use at.Use the night mode, or adjust your screen brightness to find the perfect lighting for any environment.Easily find a word or a character anywhere in the book with the powerful search feature.Highlight your favorite passages and add notes with the built-in bookmarking features.Choose from different font sizes and five easy-to-read page modes.ADE’s support for EPUB3 standard allows you: consistent rendering of audio and video content dynamic image resizing without loss in clarity support for multi-column layouts, interactive quizzes, and math formulas. Organize your books into a beautiful custom library.Įxperience gorgeous media rich books filled with interactive features, videos, and more. Extend your reading experience by transferring books from your personal computer to your iPad. Borrow ebooks from many public libraries for use with ADE. Use it to read EPUB and PDF books, both online and offline. Adobe Digital Editions (ADE) is free-to-download and use, and completely ad-free. One eBook reader for all your Adobe DRM protected books across your iPad, Mac or PC.
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It is built in 370+ video and audio codes, thus you can convert any video to the best video formats for your Mac, be it MOV, MP4 or M4V. Don't worry, the world's No.1 fast video converter for Mac is ready for help. Consequently, you will need a professional Mac video converter for help. Your overwhelming video files are not all created in the best Mac video formats like MOV, MP4 and M4V, then video conversion process from the Mac unsupported videos to the video format that Mac can best recognize seems to be of top priority. Part 3: How to Convert Unfriendly Videos to Mac Best Video Formats with Ease? Tips: To Unlock protection protection from iTunes M4V videos, you can check the well-known video converter for Mac for help. The copyright of M4V files may be protected by using Apple's FairPlay DRM copy protection. Generally, Apple uses M4V encode video files, such as TV episodes, movies, and music videos, in its iTunes Store. M4V (A video container format developed by Apple and is very similar to the MP4 format.) But MP4 files encoded with MPEG-4 video or H.264 (preferred) video are also considered as one of the best video formats compatible with Mac OS. Between the native QT7 codecs, the Perian ones, and Flip4Mac, you are mostly covered. Attention shall be paid it's possible that what's going on is that they use the MPEG4 architecture but they're using a weird codec. MP4 (MPEG 4) is actually a standard that Apple really pushed with Quicktime 6. MP4(A digital multimedia format most commonly used to store video and audio, subtitles and still images.) It is known to have the best video quality of all three streaming formats listed here. Naturally, MOV is the standard and best video format for Mac. MOV video file uses a proprietary compression algorithm developed by Apple Computer. MOV (A filename extension for the QuickTime multimedia file format) The following will list the best video format Mac supports and codecs you will need for a successful playback on your Mac (MacBook/MBP/iMac). In other words, only when the supported video comes with specific codec that Mac supports can your OS X play the file smoothly. ![]() ![]() The net result of this is that it's not just about whether the Mac can play the format or not, it's whether there is any Mac software to support the codec within the file too. The video and audio formats listed above are fair-weather fan of Mac computer. Download for Mac Download for PC Part 2: What is the Best Video Format for macOS? This work is critical and not easy to do, but can be worth it if the employee comes on and delivers results. So in terms of mitigating risks, what did our client and Ag1Source do? First, there were many long conversations and background checks making sure the candidate did not have a chronic problem with drinking and that this DUI was an isolated incident. The client put an individual vehicle policy in front of the candidate that mitigated their risk and the employee is hitting the ball out of the park and surpassing all goals. We approached one of Ag1Source’s longest and best clients with a chance to hire a true “rockstar” salesperson with an ability to manage other salespeople as well. First, we had a candidate that had been released from a major seed company because of a DUI infraction. We tried to estimate it for the three example candidates in this article and it quickly rose into the hundreds of thousands of dollars lost by disrupting that career path.įor our bright spot, we’d like to introduce an opportunity in the form of two examples we helped facilitate with our clients. However, the long-term earnings lost by not working up to one’s career capabilities, because of many large company policies against EVER hiring someone with a DUI, is significant. The company has now established a zero-tolerance policy.Īcross these three examples, when each person totaled the fines, legal fees, insurance costs and time away from work, the cost of the actual DUI was easily near the amounts mentioned on the billboards. The employee was let go and has since found a role working for a competitor in an hourly position with much less responsibility and compensation. However, the company’s insurance provider had a big problem with the retention of this employee due to the perceived risk for an organization in an industry that is already filled with liability risks. This particular employee was pulled over for a DUI, but was not in a driving role for the company. Our last example is a management team member at a highly thought of and recognized agronomy retail organization. However, the company’s insurance underwriters still had a problem with the perceived risk and he was unable to get hired. We helped this candidate get very deep into interviews with a client that has employees run their own vehicles and receive reimbursement. In agriculture, most, if not all, sales roles involve company vehicles. This candidate had asked us to find him something in a sales role. His company worked very hard to keep him, but in the end, they were not willing to have an employee drive a company vehicle with a DUI on his record. He was out with customers, had one too many and was pulled over on the way home. Our second candidate was one of the top five sales representatives at one of the three major farm equipment manufacturers. This candidate has now been left to look for work across a much larger geography, with less income potential. In this case the DUI didn’t cause his termination, but now he can’t work for most of the major companies in the chemical or seed space, where he has a wealth of experience, because many of those companies have stated “No Tolerance” policies for a DUI on your record. Independent of the DUI event, his company was going through some downsizing and he was let go. He had recently moved to another company and was pulled over and ticketed for DUI. Our first candidate was at the executive level for a major crop inputs manufacturing company. Let’s start with the tougher situations and work towards the bright spot at the end. In the past 12 months, we have actively worked with several candidates that had fairly recent DUIs. With that said, we wanted to introduce you to the REAL impact of a DUI on your record. No one wants a DUI, much less a life-taking accident, especially coming back from a company holiday party. ![]() This reminder is very timely as we come into the holiday season. ![]() To begin, we strongly recommend a small reminder to all employees to be safe and always turn over the keys or find another ride when drinking. In this article, we share a few stories that address the lifetime career costs and a potential bright spot for some organizations and hiring managers. At Ag1Source, we have noticed that the impacts of a DUI can actually stretch way beyond the actual direct legal and insurance costs due to a lifetime of limited employment opportunities. ![]() Current Topics in Medicinal Chemistry Special FBDD.It is the sum of internal energy and flows energy.If you have the resources, it may be worthwhile characterizing the thermodynamic profiles of your fragment hits, and – perhaps – looking more closely at those that show enthalpically-driven binding. Obtaining thermodynamic parameters for small-molecule protein interactions has historically been challenging, but in recent years miniaturization and improvements in technology have brought ITC into more non-specialist labs. Compound 19 shows a highly favorable binding enthalpy, and is the most potent and ligand-efficient of any of the three elaborated molecules. However, this was a relatively modest boost for the more entropic compound 3 to compound 20, but considerably larger for the enthaplically-driven compound 2 to compound 19. In compound 3, the fluorine points towards the hydrophobic wall of the protein.Īdding a 4-benzylamide substituent onto each of these molecules led to improvements in activity. Interestingly, the structure of compound 2 shows a specific interaction between the fluorine atom and a main-chain NH of the protein. The researchers determined high-resolution crystal structures for all three of these molecules bound to hCA II. In contrast, compound 3 has a similar enthalpy of binding as compound 1 but increased entropy. However, a look at the thermodynamic parameters reveals that the affinity of compound 2 is driven by a sizable improvement in enthalpic binding, partially offset by lowered entropy. If you were choosing between these fragments solely on the basis of affinity or ligand efficiency, it would be reasonable to choose compound 3, and in fact a search of the literature turned up 15 carbonic anhydrase inhibitors that contained the 3-fluorobenzenesulfonamide substructure and none that contained the 2-flurobenzenesulfonamide substructure. In contrast, adding a fluorine to the 3-position (compound 3) improves the potency by seven-fold and also improves the ligand efficiency. Adding a fluorine group to the 2-position of benzenesulfonamide (compound 2) improves the potency almost three-fold but lowers the ligand efficiency. Benzenesulfonamide (compound 1, below) is a known binder, and the researchers studied the thermodynamics of 20 derivatives of this molecule using isothermal titration calorimetry (ITC), taking care to generate high-quality binding data. The researchers used human carbonic anhydrase (hCA II), a venerable work-horse of biophysical studies. In a new paper in ChemMedChem, Andrew Scott and colleagues at Pfizer show how fragments that owe more of their binding affinity to enthalpy make better starting points for optimization than do fragments whose binding is more entropic, even if the entropic fragment is more potent. Optimizing enthalpy is usually more difficult than optimizing entropy: engineering a polar interaction requires more precision than adding a bit of grease. ![]() On a (very) simplistic level, enthalpic binding comes via specific molecular interactions, such as hydrogen bonds, while entropic binding results from nonspecific hydrophobic interactions. Affinity, or binding energy, can be dissected into two components: enthalpy and entropy. The earliest stages of lead discovery usually focus on obtaining a molecule with decent affinity for a given target. Type - Type your name and Adobe will generate a signature using a signature-style font.Provide a signature using one of three methods:.If you would like to reset your signature, please consult the Resetting Your Saved Signature section below then come back to this step. Note: If you have done this before, your saved choice will appear instead of the Add Signature option. (You can also choose the black circle next to the Sign tool to change the color of your signature, if needed.) Choose the Sign tool to sign the document. The Fill & Sign ribbon will become available at the top of the page, and the Add Text tool will be selected by default.Note: The blue Request signatures button visible at this point requires access to Adobe Sign Enterprise. You'll be asked What do you want to do? Select the blue button Fill and sign.Select Fill & Sign from the right-side Tools menu.Open the PDF file you would like to sign in Adobe Acrobat Pro DC.For large volume signature requests or complex workflows, Adobe Sign Enterprise may be a better solution. For document creators requesting signatures from others, emailing the document to the signer along with a link to these instructions may fulfill their needs. Unfortunately, Adobe prohibits any exceptions to these access rules.įill & Sign is intended to be used by the signer of a document - it does not provide functionality for document creators who need someone else to sign their document. If you aren't sure, refer to the Affiliation Resource Access Rules for your UO affiliation. current staff and faculty) will have access to use this functionality. Adobe's Fill & Sign functionality is available for free within the Adobe Acrobat Pro DC app - UO members who have access to Adobe's Creative Cloud and Document Cloud (i.e. ![]() While one memory is transferring data from/to the shared memory, the other is supplying the core processor with data. introducing two small programmable fast memories (Twins) between the processor and the shared bus interconnect. This significant enhancement is achieved by. The proposed architecture can effectively support 32 DSPs in contrast to a maximum of 4 DSPs supported by existing DSP-based bus-interconnected systems. This dissertation introduces, investigates, and evaluates a low-cost high-speed twin-prefetching DSP-based bus- interconnected shared-memory system for real-time image processing applications. The Orthophoto image could provide visual interpretation such as the individual trees structure, plant density, and parcel boundary area, while DEM could asses tree's height information and terrain topography with accuracy 3-6 pixel or 0.5-2.5 m. The Average geometric accuracy can be obtained up to 3 pixels or equivalent to sub-meter accuracy, while the production time can be reached more than 500Ha a day. The basic products of the system are Orthophoto Image and Digital Elevation Model (DEM). This system has the ability to produce imagery with spatial resolution <10 cm, measuring parcel area, assess the individual trees or plants stock, and topography. The system consists of aerial platforms from R/C plane, point and shoots digital cameras, data processing with digital photogrammetric: structure from motion algorithms, and free open source-GIS for visualizing. So, the UAV-Based remote sensing system should have characteristics such as cost-effective, fast in producing, easy in operation by local staff, and good geometry accuracy (sub-meter). Some of the information for land preparation, cadaster boundary, vegetation monitoring, plant healthy, and stock valuation are required periodically. This paper shows some practical experiences of using Unmanned Aerial Vehicle-(UAV) based platform for remote sensing in supporting precision agriculture mapping. This design method, therefore, will contribute to the application of holonomic vehicles due to the realization of holonomic functionality and simplicity. Further, the construction method is simple and can satisfy the accuracy requirement. This study is the first attempt to apply air-based propulsion to a land-based holonomic vehicle. Simulation results showed that with the increase of propulsion efficiency, the velocity can achieve more than 5 m/s if the efficiency is 70%. The prototype can move at a velocity of approximate 0.558 m/s with an efficiency of 18.55%. For the establishment of the methodology, the data, including propeller size, rotation per minute, velocity, thrust, efficiency, etc., were measured or calculated. ![]() Only two motors were applied, one for propeller rotation and the other for the adjustment of the angle of thrust. A prototype with three roller balls was developed with a propeller for the propulsion of a triangular holonomic vehicle. Air-based propulsion was applied to a land-based holonomic vehicle. This paper aims to present the design and construction of a novel holonomic mechanism to simplify the system. For such a system, more driving motors and precise transmission mechanisms are necessary, which makes the control and fabrication complicated. Holonomic vehicles with wheels such as ball wheels can move in any direction without rotating. Results show that the new medium range UAV concept can be applied to realize long endurance flight. Flight tests were successful and UAV performance was confirmed. Wing structure strength was analyzed, and then the engine–propeller configuration for UAV power generation was selected. Aerodynamic performance analysis of the wing was conducted using a four method calculation to obtain the design configuration. A pusher high wing twin boom aircraft was chosen because of its better stability. In this study, the design activities included comparing to an existing aircraft to determine the initial sizing for the UAV. The aircraft was designed with a wing span of 5.5 meters and payload capacity of 30 kg, considered to be an optimum solution for aerial photography. Development activities of medium range of UAV have been conducted at LAPAN (National Institute of Aeronautics and Space). UAV based remote sensing for supporting environmental forestry planning, ecosystem preservation, and agricultural planning in Indonesia are very potential. |
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